Neglected Tropical Diseases

First responder." As a parent or caregiver have you ever thought of yourself as one? As you know your child best, you rely on your gut instinct if something is amiss. Though you may not qualify in the strictest sense, lacking the training needed for the job which entails dealing with emergencies, think about the following. You are the first one to come to the scene, check the situation, and provide assistance before medical help arrives. You are the primary source of information for which the pediatrician forms the basis of his initial diagnostic impression. In children, emergency room consults revolve around respiratory concerns, allergic reactions, dehydration, injuries, or infections. Focusing on the latter, allow me to provide you with the minimal basics so as to avoid that trip to the hospital. ADVERTISEMENT In general, infections are either bacterial or viral. Fortunately, most common childhood illnesses are viral in nature, self-limiting, and only require suppor...

Mpox (formerly known as monkeypox) and chickenpox are two contagious viral diseases. They both have "pox" in their names because they cause pockmark skin lesions. But mpox is caused by a virus similar to smallpox, while a type of herpesvirus causes chickenpox. While they share similar symptoms (like fever, fatigue, headaches, and a blistering rash), mpox and chickenpox differ by how the viruses are spread, the locations of the rashes, the populations they most commonly affect, and how each is treated. This article describes the differences between mpox and chickenpox in symptoms, causes, diagnosis, and treatment. If you have a rash, be sure to see a healthcare provider for a diagnosis so that you can receive the appropriate treatment. rbkomar / Getty Images Symptoms No less than three dozen viral diseases have "pox" in their names, the most familiar of which are chickenpox, smallpox, and mpox. All of these diseases s...

Just like any other sexually transmitted infection, trichomoniasis can also travel from one person to another through unprotected sexual activity. According to the US Centers for Disease Control and Prevention (CDC), sexually active people can get trich by having sex without a condom with a partner who has trich. "In women, the infection is most commonly found in the lower genital tract (vulva, vagina, cervix, or urethra). In men, the infection is most commonly found inside the penis (urethra). During sex, the parasite usually spreads from a penis to a vagina, or from a vagina to a penis. It can also spread from a vagina to another vagina," the health body explains.

It comes as both New South Wales and Victorian health authorities say they are seeing a spike in cases among children. Strep A, a bacterium found in the throat and on the skin, led to the death of two children in 2022, while "many others" required intensive care treatment, according to Safer Care Victoria. Group A Streptococcus infections are rising in Australia, with two states now on alert over cases. (CDC) Having the bacteria – also known as group A streptococcus – is actually common, and many people who have it often have a mild sore throat and fever or even no symptoms. But it can turn deadly and cause permanent disabilities in cases where it develops into a more severe invasion: invasive group A streptococcal disease (iGAS). General Practitioner Dr Brad McKay has told Today people become very sick with Strep A when the bacteria "digs into and invades the rest of your body". That is when symptoms tend to escalate. Dr Brad McKay, a GP, has outlined the s...

Image Credit: Supplied "Wellth has all alternative therapies under one roof" Dr Khalid Shukri, Physician, Anti-Aging, Regenerative Medicine and Functional and Metabolic Medicine What is Wellth and how is it different from other wellness centres? Wellth is a unique health experience. At Wellth we believe in good medicine which incorporates any medical practices that are proved to improve health and improve the lifestyle of our visitors. Unlike other health clinics – Wellth has all alternative therapies under one roof. Our clinicians thoroughly discuss cases to assess various treatment modalities and create the optimum treatment plan. This allows Functional medicine doctors to work directly with homeopaths and chiroprac...

Abstract The transport of the CagA effector into gastric epithelial cells by the Cag Type IV secretion system (Cag T4SS) of Helicobacter pylori ( H. pylori ) is critical for pathogenesis. CagA is recruited to Cag T4SS by the Cagβ ATPase. CagZ, a unique protein in H. pylori , regulates Cagβ-mediated CagA transport, but the underlying mechanisms remain unclear. Here we report the crystal structure of the cytosolic region of Cagβ, showing a typical ring-like hexameric assembly. The central channel of the ring is narrow, suggesting that CagA must unfold for transport through the channel. Our structure of CagZ in complex with the all-alpha domain (AAD) of Cagβ shows that CagZ adopts an overall U-shape and tightly embraces Cagβ. This binding mode of CagZ is incompatible with the formation of the Cagβ hexamer essential for the ATPase activity. CagZ therefore inhibits Cagβ by trapping it in the monomeric state. Based on these findings, we propose a refined model for the transport of ...