Neglected Tropical Diseases

NewsDesk  @bactiman63 The Philippines Department of Health (DOH) reports confirming human cases of anthrax in Sto. Niño, Cagayan after being exposed to infected dying carabaos — some of which were butchered and consumed as meat, according to a PhilStar report. This comes on the heels of recent reports of the anthrax deaths of four carabaos, two of which were said to have been sold as meat to residents. The DOH reiterates that the Anthrax spread in Cagayan should be treated as a "health event" due to exposure to animals and "not connected to any act of terrorism." [embedded content] Anthrax is a bacterial pathogen in  livestock  and wild  animals . Ruminants such as bison, cattle, sheep and goats are highly susceptible, and horses can also be infected. Anthrax is a very serious  disease  of livestock because it can potentially cause the rapid  loss  of a ...

The Columbus City Council and the Lowndes County Board of Supervisors on Thursday agreed to accept a $200,000 offer from Apex Ammunition to purchase the jointly-owned former Maxxim Medical building and the associated 7.8 acres off Yorkville Park Square. The decision was made during the city's work session on Thursday, following a roughly hour-long executive session with the supervisors. Keith Gaskin "That was the first time the city and the county had been able to sit down together and talk about the different pros and cons," Mayor Keith Gaskin said. "Obviously everybody was interested in selling the facility. The question was looking at the value of the property and the building. I think everybody was wanting to make sure we got the best deal that was a win-win for our citizens long term." Board of Supervisors President Trip Hairston said the agreement was favorable to the county. Trip Hairston "The board of supervisors we...

Monkeypox virus (MPVX) is a double-stranded deoxyribonucleic acid (DNA) virus from the genus Orthopoxvirus , family Poxviridae. Many cases of MPVX infection are currently seen worldwide. Although the majority of cases reported are not severe, basic precautionary measures are key to preventing this infection from turning into a catastrophic pandemic. We report a case of a 54-year-old male with no high-risk behavior who developed a sudden uncharacteristic monkeypox virus rash while on a flight from Nigeria. Introduction Monkeypox virus (MPVX), a rare zoonotic infection, was first reported in 1958 as an outbreak of a pox-like disease in monkeys in Copenhagen, Denmark [1]. Nearly after a decade, on September 1, 1970, the first case of human MPXV infection was diagnosed in an infant who was admitted to the hospital in the Democratic Republic of Congo (DRC). The boy presented with a smallpox-like disease from which MPXV was isolated [2,3]. MPXV is&nbs...

Xing W, Liao Q, Viboud C, Zhang J, Sun J, Wu JT, Chang Z, Liu F, Fang VJ, Zheng Y, et al. Hand, foot, and mouth disease in China, 2008–12: an epidemiological study. Lancet Infect Dis. 2014;14(4):308–18. Article  Google Scholar  Zhuang Z, Kou Z, Bai Y, Cong X, Wang L, Li C, Zhao L, Yu X, Wang Z, Wen H. Epidemiological research on hand, foot, and mouth disease in Mainland China. Viruses. 2015;7(12):6400–11. Article  CAS  Google Scholar  Zou X, Zhang X, Wang B, Qiu Y. Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases. Braz J Infect Dis. 2012;16(5):457–65. Article  Google Scholar  Huang Y, Deng T, Yu S, Gu J, Huang C, Xiao G, Hao Y. Effect of meteorological variables on the incidence of hand, foot, and mouth disease in children: a ...

Many Houstonians view Urgent Care Near Me as the place to go when medical needs arise. Its nonexistent wait times, high-quality physicians and quick access to advanced technology certainly beat the unavoidable frustrations of typical hospital emergency rooms. Lesser known but equally important is Urgent Care Near Me's telemedicine service, which provides the same exceptional health care at even more convenience to patients. Darrell Clark, Chief Operating Officer, said the operations' success is due to the staff's dedication to premium care. "Our goal is to offer a higher quality than just your standard telemedicine service and also a higher quality of care in our urgent care versus your typical urgent care—especially with RSV, flu and COVID-19 numbers creeping up. It's a real battle right now," Clark said. Urgent Care Near Me opened on Richmond Avenue in January, providing a full gamut of services to residents who reside near The Galleria—which Clark said wa...

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Abstract An essential step in bacterial transformation is the uptake of DNA into the periplasm, across the thick peptidoglycan cell wall of Gram-positive bacteria, or the outer membrane and thin peptidoglycan layer of Gram-negative bacteria. ComEA, a DNA-binding protein widely conserved in transformable bacteria, is required for this uptake step. Here we determine X-ray crystal structures of ComEA from two Gram-positive species, Bacillus subtilis and Geobacillus stearothermophilus , identifying a domain that is absent in Gram-negative bacteria. X-ray crystallographic, genetic, and analytical ultracentrifugation (AUC) analyses reveal that this domain drives ComEA oligomerization, which we show is required for transformation. We use multi-wavelength AUC (MW-AUC) to characterize the interaction between DNA and the ComEA DNA-binding domain. Finally, we present a model for the interaction of the ComEA DNA-binding domain with DNA, suggesting that ComEA oligomerization may provide a pulling ...